Sandra % % Sefa,维兰德,华盛顿特区Florian % Helmholz, Heike % Zeller-Plumhoff, Berit % Wennerberg,安% Moosmann,朱利安% Willumeit-Romer,雷吉娜%加利,西尔维亚2022% % D J生物材料科学前沿% C % F % G英语%雷竞技rebat K可降解植入物,随着含镁植入,降解产物,同步辐射微型电脑断层扫描,微x射线荧光,骨愈合% Q % 10.3389 R / W fbiom.2022.925471 % % L % M % P % 7% 8 2022 - 9月20 % 9原始研究% # % !长期体内镁合金的降解行为% * % < % T评估长期体内镁合金的降解行为——一个高分辨率的同步辐射微计算机断层扫描研究V % U //www.thespel.com/articles/10.3389/fbiom.2022.925471 % 1% 0期刊文章% @ 2813 - 3749 % X可降解镁(Mg)植入物植入技术正在成为一个潜在的改变游戏规则的情况下植入暂时支持骨从而避免二次手术植入物移除。雷竞技rebat然而,降解率的改变的后果骨折愈合和本地化的退化和合金产品在长期内仍然未知。在这项研究中,我们提出的长期骨整合三种不同的可降解镁合金,Mg-10Gd, Mg-4Y-3RE Mg-2Ag,植入兔股骨6和9个月。此外,我们调查的影响,血液在体内pre-incubation上述合金的性能。使用基于高分辨率同步辐射微计算机断层扫描,骨植入物接触(BIC),骨体积分数(BV /电视)和植入物的形态进行了研究。元素的痕迹已经使用微x射线荧光特征。定性的组织学评估周围的骨头也被执行。成熟骨形成在所有三种类型的植入和Ca以及P代表部分降解层与骨头亲密接触。 Blood pre-incubation prior to implantation significantly improved BIC in Mg-2Ag screws at 9 months. Despite different implant degradation morphologies pointing toward different degradation dynamics, Mg-10Gd, Mg-4Y-3RE and Mg-2Ag induced a similar long-term bone response based on our quantified parameters. Importantly, RE elements Gd and Y used in the alloys remained at the implantation site implying that they might be released later on or might persist in the implantation site forever. As the bone formation was not disturbed by their presence, it might be concluded that Gd and Y are non-deleterious. Consequently, we have shown that short and mid-term in vivo evaluations do not fully represent indicators for long-term osseointegration of Mg-based implants.