作者=郑宿州农村,锅,李平,施王中原,王泽,昙花TITLE =卵巢胰岛素抵抗患者的敏感性显著降低接受体外受精和胚胎移植体积= =前沿生理学杂志》12年= 2022 URL = //www.thespel.com/articles/10.3389/fphys.2021.809419 DOI = 10.3389 / fphys.2021.809419 ISSN = 1664 - 042 x文摘=卵巢敏感性可能影响体外受精和雷竞技rebat胚胎移植的结果(IVF-ET)。本研究的目的是探索卵巢敏感性指数之间的关系(OSI)和传统卵巢反应制造商和观察OSI和胰岛素抵抗(IR)的关系。患者加入这项研究包括131名患有多囊卵巢综合征(PCOS)和红外(PCOS-IR), 52 PCOS患者没有红外(PCOS-N), 164名患者与红外控制(control-IR), 133名患者没有红外控制(control-N), 295 IR患者,184例non-IR, 183 PCOS患者,297例控制(non-PCOS患者)。所有患者接受标准长期协议或促性腺激素释放激素(GnRH)拮抗剂协议诱导卵泡发育。这两个协议下调垂体功能或封锁了垂体促黄体激素(LH)分泌促性腺激素拮抗剂。这两个协议都可以阻止过早LH激增因为过早黄体化不是有利于卵泡发展。所有患者接受体外受精或胞浆内精子注射(ICSI)。胚胎移植是根据每个病人的具体情况。OSI是显著降低患者的IR。OSI有显著的关系,她们血液中的抗苗勒氏管激素(抗苗勒氏管激素),窦的卵泡数(亚),基底LH /促卵泡激素(FSH),占主导地位的卵泡数量触发天,检索卵母细胞,胚胎数,和高质量的胚胎数。 OSI had a significant negative relationship with age, body mass index (BMI), basal FSH, initial dose of Gn, and total dose of Gn. The receiver operating characteristic (ROC) curve of OSI demonstrated a better accuracy in distinguishing patients with positive pregnancy and clinical pregnancy, with an area under the curve (AUC) of 0.662 (95% CI, 0.598–0.727) and 0.636 (95% CI, 0.577–0.695), respectively. Patients could get a higher rate of dominant follicle count (p < 0.0001) through the treatment of standard long protocol when compared with GnRH antagonist protocol. The OSI has a significant correlation with traditional ovarian response markers and could be a good predictor of positive pregnancy and clinical pregnancy for patients with IR.